The decision came a few hours following a 2-1 defeat by Germany in Stuttgart during their preparation for the tournament, which will be held in North America next summer. Ghana also lost 5-1 in Austria on Friday.
"The Ghana Football Association (GFA) have parted ways with the Head Coach of the senior men’s national team (Black Stars), Otto Addo, effective immediately," it said in a statement.
Former Borussia Dortmund player Otto Addo, appointed in March 2024, failed to qualify Ghana for the 2025 Africa Cup of Nations despite having Premier League players Antoine Semenyo and Mohammed Kudus in his squad.
He won eight matches and lost nine in 22 games in charge.
Ghana, who reached the World Cup for the fifth time, are in Group L along with Croatia, England , and Panama.