Pisa were victorious in the league for the first time since November last week, and needed to weather the early storm here if they were to reignite their fleeting survival hopes.
However, in the opening 10 minutes, a dreadful square pass from Stefano Moreo was pounced on by Assane Diao, who marked his first start since mid-December by driving at the open Pisa defence and slotting into the bottom corner.
Diao’s long injury lay-off clearly hadn’t left the forward rusty, as he created Como’s second just before the half-hour mark.
The Lariani caught Pisa on a counter, which Diao led down the right, before cutting inside and picking out Anastasios Douvikas to bury in at the near post for his third H2H goal of the campaign.
Cesc Fabregas’ men may have boasted a comfortable two-goal lead at the break, but an injury to Jesus Rodriguez, which forced him off, meant the hosts didn’t come through the first half unscathed.
His replacement, Martin Baturina, was on target just three minutes after the restart as Como well and truly put the game beyond their beleaguered visitors. The Croatian picked the ball up on the inside right, held off the challenge of Simone Canestrelli and drove to the edge of the area before drilling a shot into the bottom corner.
Further pain was on the way for Pisa, who thought they had responded when substitutes Filip Stojilkovic and Henrik Meister both finished off well-worked moves, only for each strike to be chalked off for offside in the build-up.
While a comeback never looked feasible, those two decisions knocked the stuffing out of Pisa. They conceded again in the 75th minute, too, with Nico Paz sweeping home from Alberto Moreno’s cutback for his first home league goal since October.
Como then put the seal on a perfect afternoon with a fifth late on in simple fashion, as Nicolas Kuhn’s square pass was turned into an empty net by Maximo Perrone to take the aggregate scoreline across this season’s two H2Hs to a whopping 8-0.
As a result, Como pulled three points clear of Juventus in fourth, while Pisa remain nine points adrift of safety inside the relegation zone and without an away win since returning to the top flight last year.