That will dominate the headlines, but there are seven other crucial games that all have a bearing on either CAF qualification, MTN8 places next season or relegation.
Here are the talking points ahead of them.
The big one
The big one this weekend is the Soweto derby on Sunday, and both teams come into the clash in good form.
Chiefs beat Pirates in the Nedbank Cup final last May, but aside from that, the Buccaneers have dominated this fixture in recent times with six wins in the last seven meetings.
That is as good a run as they have ever had in the derby since it was first played in 1970.
But Chiefs come into the game on the back of winning 16 points from the last 18 available, form that has seen them all but secure third place in the league.
Pirates, of course, are in desperate need of a win to fulfil their title ambitions and currently lead second-placed Mamelodi Sundowns by a point, though they have played a game more. They simply cannot afford any slip-ups.
The Buccaneers romped to a 3-0 win when the teams met in late February, though Chiefs were depleted by injury and will expect to put up a much better showing this time round.
There has not been a draw in the last 17 competitive meetings since 2019. In that time, Pirates have won nine and Chiefs eight. The last draw was 2-2 in the Telkom Knockout in November 2019.
Sundowns look to get back to winning ways
Sundowns fans will be hoping for a Chiefs win as they go to Richards Bay on Sunday looking to regain top spot in the league.
The Brazilians were held to a 1-1 draw in midweek by Stellenbosch, and with the games coming thick and fast, the rest of the season will be a test of endurance as much as anything else.
After this clash, they have home-and-away matches against Polokwane City next week as they get their league games done ahead of the CAF Champions League final.
The draw with Stellenbosch ended a run of 10 wins in a row for Sundowns in the league, while Richards Bay have also found some late-season form to take seven points from the last nine available.
It is fair to say Sundowns have been utterly dominant in this fixture, winning all 10 previous meetings and scoring 25 goals while conceding only three.
But the weird way the fixtures have worked out means this is the first time they have travelled to Richards Bay since December 2024. The last three clashes in league and cup have been in Pretoria, with Sundowns scoring 11 goals and conceding one.
Parker coaching bow
Former Kaizer Chiefs and Bafana Bafana striker Bernard Parker will make his bow as a head coach when he leads ailing TS Galaxy in their crucial home clash against Magesi FC on Sunday.
Galaxy sacked coach Adnan Beganovic on Thursday, just over a week out from the Nedbank Cup final, where they face Durban City next Saturday.
That was on the back of a horror run in the league where they have lost nine and drawn one of their last 10 games to slip perilously close to the relegation zone.
If they lose to Magesi this weekend, they could be sucked right into the equation for the bottom two. At the moment, they are five points clear of second-bottom.
Magesi are coming off the back of a rare win after a 5-2 pummelling of Durban City last time out, the first time they have scored five goals as a top-flight club.
And Magesi are unbeaten against Galaxy in four previous meetings, winning three to go with a draw. That includes a 2-1 victory earlier this campaign.
Magesi remain the only top-flight side yet to claim a victory on the road this season, with five draws and eight defeats.
Orbit hope for lift-off
Since Durban City qualified for the Nedbank Cup final next weekend, they have lost three league games in a row, including that surprise 5-2 defeat at struggling Magesi FC.
They will hope to turn that around when they face an Orbit College side that have slipped to the bottom of the league table and have won just once in their last 15 games in all competitions, with three draws and 11 defeats. That single victory was away at TS Galaxy last month.
City had at one stage hoped to finish in the top three and qualify for the CAF Confederation Cup next season, but are now looking to cling on to a top-eight place to enter the MTN8.
Their run means just three points separate them in sixth and Stellenbosch FC in ninth.
Victory could take Orbit out of the bottom two if other results go their way, but a draw will likely keep them bottom given their inferior goal difference.
City won the reverse fixture 3-0 in December, while their two meetings in the second tier last season ended in draws.
Usuthu cling on to third-place hopes
AmaZulu’s hopes of finishing third look to have evaporated as they have taken only two points from the last nine available, but a home clash with Chippa United should give them the chance to get back on track.
Usuthu trail third-placed Chiefs by seven points and have played a game more, so would likely need to win their remaining five games to stand any chance.
Chippa are not out of the relegation woods yet despite improved recent form. They are four points ahead of the relegation play-off position and five from the automatic drop zone. That said, one more win could well be enough.
They have been pretty poor travellers, with a single win in 12 on the road this season, along with four draws and seven defeats, while AmaZulu beat them 3-0 away in the reverse fixture in November.
Usuthu have won four of the last six meetings, with one draw and one defeat, but overall Chippa have held sway with nine wins to seven and five draws in 21 previous meetings. That includes six wins in 10 visits to Durban, with one draw and three defeats.