Trippier joined Newcastle in January 2022, with the club sat in the Premier League relegation zone, and was a catalyst for their ascent back up the table.
The England international has made 157 appearances for Newcastle and helped guide them to two Champions League finishes as well as a first domestic trophy in 70 years during his tenure.
“The time has come to leave this amazing club after four and a half years. This is where I’ve felt most at home. It’s emotional, and I’m really going to miss it," Trippier said.
“I want to say a massive thank you to the supporters for all the support through the good and the bad times. You’ve always supported me, always stood by me."
The 35-year-old captained Newcastle on several occasions and was the first Magpies player to captain the England national team since Michael Owen in 2005.